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TAO3
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily |
| Chromosomal Location of human Ortholog: 12q24.23 |
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Cellular Component:
cytoplasm; plasma membrane
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Molecular Function:
ATP binding; protein binding; protein kinase inhibitor activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cellular response to DNA damage stimulus; DNA repair; intracellular signal transduction; MAPK cascade; mitotic G2 DNA damage checkpoint signaling; negative regulation of catalytic activity; negative regulation of JNK cascade; neuron projection morphogenesis; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of MAPK cascade
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Reference #:
Q9H2K8
(UniProtKB)
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Alt. Names/Synonyms: CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC-A; JIK; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine/threonine-protein kinase TAO3; STE20-like kinase; TAO kinase 3; TAO3; TAOK3; Thousand and one amino acid protein 3
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Gene Symbols: TAOK3
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Molecular weight:
105,406 Da
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Basal Isoelectric point:
6.83
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Microtubule Dynamics
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Regulation of P38 MAPKs
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