TAO3 Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Chromosomal Location of human Ortholog: 12q24.23
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  ATP binding; protein binding; protein kinase inhibitor activity; protein serine kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular response to DNA damage stimulus; DNA repair; intracellular signal transduction; MAPK cascade; mitotic G2 DNA damage checkpoint signaling; negative regulation of catalytic activity; negative regulation of JNK cascade; neuron projection morphogenesis; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of stress-activated MAPK cascade; protein autophosphorylation; protein phosphorylation; regulation of MAPK cascade
Reference #:  Q9H2K8 (UniProtKB)
Alt. Names/Synonyms: CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC-A; JIK; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine/threonine-protein kinase TAO3; STE20-like kinase; TAO kinase 3; TAO3; TAOK3; Thousand and one amino acid protein 3
Gene Symbols: TAOK3
Molecular weight: 105,406 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene