SRRT iso3 Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Belongs to the ARS2 family. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 7q22.1
Cellular Component:  cytoplasm; nucleoplasm; protein-containing complex
Molecular Function:  DNA binding; protein binding
Biological Process:  cell proliferation; mRNA splicing, via spliceosome; neuronal stem cell population maintenance; positive regulation of neurogenesis; primary miRNA processing; regulation of transcription, DNA-templated; response to arsenic-containing substance; snRNA transcription by RNA polymerase II
Reference #:  Q9BXP5-3 (UniProtKB)
Alt. Names/Synonyms: ARS2; arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; arsenite-resistance protein 2; ASR2; MGC126427; OTTHUMP00000211333; OTTHUMP00000211334; OTTHUMP00000211335; OTTHUMP00000211336; Q9BXP5-3; Q9BXP5-4; Q9BXP5-5; serrate; serrate RNA effector molecule; Serrate RNA effector molecule homolog; serrate RNA effector molecule homolog (Arabidopsis); serrate RNA effector molecule homolog isoform c; serrate RNA effector molecule homolog isoform e; serrate, RNA effector molecule; SRRT; SRRT iso3
Gene Symbols: SRRT
Molecular weight: 100,537 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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SRRT iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein