STLK6
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in heart, skeletal muscle, testis, liver and colon. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily |
Chromosomal Location of human Ortholog: 2q33.1 |
Cellular Component:
aggresome; cytoplasm; cytosol; nucleus; serine/threonine protein kinase complex
|
Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activator activity
|
Biological Process:
activation of protein kinase activity; cell cycle; cell morphogenesis; JNK cascade; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein export from nucleus; protein phosphorylation
|
Reference #:
Q9C0K7
(UniProtKB)
|
Alt. Names/Synonyms: ALS2CR2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; MGC102916; PAPK; PRO1038; Pseudokinase ALS2CR2; STE20 related adaptor beta; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta; STLK6; STRAB; STRAD beta; STRADB
|
Gene Symbols: STRADB
|
Molecular weight:
47,026 Da
|
Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
|