STLK6 Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in heart, skeletal muscle, testis, liver and colon. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily
Chromosomal Location of human Ortholog: 2q33.1
Cellular Component:  aggresome; cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; protein binding
Biological Process:  activation of protein kinase activity; cell cycle arrest; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein export from nucleus
Reference #:  Q9C0K7 (UniProtKB)
Alt. Names/Synonyms: ALS2CR2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; MGC102916; PAPK; PRO1038; Pseudokinase ALS2CR2; STE20 related adaptor beta; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta; STLK6; STRAB; STRAD beta; STRADB
Gene Symbols: STRADB
Molecular weight: 47,026 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below

STLK6

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein