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STRAD
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily |
| Chromosomal Location of human Ortholog: 17q23.3 |
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Cellular Component:
cytoplasm; cytosol; intracellular protein-containing complex; nucleoplasm; nucleus; serine/threonine protein kinase complex
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Molecular Function:
ATP binding; kinase binding; protein binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activator activity
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Biological Process:
activation of protein kinase activity; G1 to G0 transition; protein export from nucleus; protein phosphorylation
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Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
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Reference #:
Q7RTN6
(UniProtKB)
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Alt. Names/Synonyms: FLJ90524; LYK5; NY-BR-96; PMSE; protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20 related adaptor alpha; STE20-like pseudokinase; STE20-related adapter protein; STE20-related adaptor protein; STE20-related kinase adapter protein alpha; STE20-related kinase adaptor alpha; Stlk; STRAA; STRAD; STRAD alpha; STRADA
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Gene Symbols: STRADA
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Molecular weight:
48,369 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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