STRAD Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activator activity
Biological Process:  activation of protein kinase activity; cell cycle arrest; positive regulation of protein serine/threonine kinase activity; protein export from nucleus
Disease: Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Reference #:  Q7RTN6 (UniProtKB)
Alt. Names/Synonyms: FLJ90524; LYK5; NY-BR-96; PMSE; protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20 related adaptor alpha; STE20-like pseudokinase; STE20-related adapter protein; STE20-related adaptor protein; STE20-related kinase adapter protein alpha; STE20-related kinase adaptor alpha; Stlk; STRAA; STRAD; STRAD alpha; STRADA
Gene Symbols: STRADA
Molecular weight: 48,369 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below

STRAD

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein