SLK Mediates apoptosis and actin stress fiber dissolution. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); SLK subfamily; STE group; STE20 family
Chromosomal Location of Human Ortholog: 10q24.33-q25.1
Cellular Component:  cell leading edge; cytoplasm; perinuclear region of cytoplasm
Molecular Function:  ATP binding; identical protein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cytoplasmic microtubule organization; protein autophosphorylation; regulation of apoptotic process; regulation of cell migration; regulation of focal adhesion assembly
Reference #:  Q9H2G2 (UniProtKB)
Alt. Names/Synonyms: bA16H23.1; CTCL tumor antigen se20-9; hSLK; KIAA0204; Long Ste20-like Kinase; LOSK; MGC133067; se20-9; Serine/threonine-protein kinase 2; SLK; SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase; SNF1 sucrose nonfermenting like kinase; STE20 like kinase; STE20-like kinase; STE20-like kinase (yeast); STE20-like serine/threonine-protein kinase; STE20-related kinase; Ste20-related serine/threonine kinase; STE20-related serine/threonine-protein kinase; STK2
Gene Symbols: SLK
Molecular weight: 142,695 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SLK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene