TIAM1 modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 11q11
Cellular Component:  cell soma; cytoplasm; cytosol; dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; intercellular junction; microtubule; nucleus; plasma membrane; postsynaptic density; synapse
Molecular Function:  ephrin receptor binding; guanyl-nucleotide exchange factor activity; kinase binding; microtubule binding; phospholipid binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Ras GTPase binding; receptor signaling protein activity; receptor tyrosine kinase binding
Biological Process:  apoptosis; brain-derived neurotrophic factor receptor signaling pathway; cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of axonogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of JUN kinase activity; positive regulation of protein binding; Rac protein signal transduction; regulation of GTPase activity; regulation of Rac protein signal transduction; regulation of Rho protein signal transduction; response to cocaine; small GTPase mediated signal transduction
Reference #:  NP_001094028 (RefSeq)
Alt. Names/Synonyms: T-cell lymphoma invasion and metastasis 1; Tiam1
Gene Symbols: Tiam1
Molecular weight: 177,162 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept