Tip60 Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134'. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Belongs to the MYST (SAS/MOZ) family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Nuclear receptor co-regulator; Nucleolus
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; Piccolo NuA4 histone acetyltransferase complex; Swr1 complex; transcription factor complex
Molecular Function:  acetyltransferase activity; androgen receptor binding; histone acetyltransferase activity; metal ion binding; peptide-lysine-N-acetyltransferase activity; protein binding; repressing transcription factor binding; transcription coactivator activity
Biological Process:  androgen receptor signaling pathway; beta-catenin-TCF complex assembly; cellular response to estradiol stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; histone H4 acetylation; negative regulation of interleukin-2 production; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; peptidyl-lysine acetylation; positive regulation of autophagy; positive regulation of protein acetylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of growth; regulation of signal transduction by p53 class mediator; response to ionizing radiation; viral process
Disease: Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities
Reference #:  Q92993 (UniProtKB)
Alt. Names/Synonyms: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 Tat interactive protein, 60kDa; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; KAT5; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP; TIP60; ZC2HC5
Gene Symbols: KAT5
Molecular weight: 58,582 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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