Tip60 a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Nuclear receptor co-regulator; Nucleolus
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; Piccolo NuA4 histone acetyltransferase complex; Swr1 complex; transcription factor complex
Molecular Function:  acetyltransferase activity; androgen receptor binding; histone acetyltransferase activity; metal ion binding; peptide-lysine-N-acetyltransferase activity; protein binding; repressing transcription factor binding; transcription coactivator activity
Biological Process:  androgen receptor signaling pathway; beta-catenin-TCF complex assembly; cellular response to estradiol stimulus; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA double-strand break processing; DNA replication; double-strand break repair; double-strand break repair via nonhomologous end joining; histone acetylation; histone H4 acetylation; negative regulation of interleukin-2 production; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; peptidyl-lysine acetylation; positive regulation of autophagy; positive regulation of protein acetylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of growth; regulation of signal transduction by p53 class mediator; response to ionizing radiation; viral process
Reference #:  Q92993 (UniProtKB)
Alt. Names/Synonyms: 60 kDa Tat-interactive protein; cPLA(2)-interacting protein; cPLA2; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 Tat interactive protein, 60kDa; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; KAT5; Lysine acetyltransferase 5; PLIP; Tat interacting protein, 60kDa; TIP; TIP60
Gene Symbols: KAT5
Molecular weight: 58,582 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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