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TACC1
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Belongs to the TACC family. Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell development/differentiation; Cytoskeletal |
| Chromosomal Location of rat Ortholog: 16q12.4 |
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Cellular Component:
cytoplasm; cytosol; microtubule organizing center
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Molecular Function:
nuclear estrogen receptor binding; nuclear glucocorticoid receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; nuclear thyroid hormone receptor binding; peroxisome proliferator activated receptor binding; protein domain specific binding
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Biological Process:
cell population proliferation; cerebral cortex development; interkinetic nuclear migration; microtubule cytoskeleton organization; mitotic spindle organization; neurogenesis; positive regulation of DNA-templated transcription; regulation of microtubule-based process
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Reference #:
NP_001004107
(RefSeq)
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Alt. Names/Synonyms: Tacc1; Tacc1a; transforming, acidic coiled-coil containing protein 1; transforming, acidic coiled-coil containing protein 1a
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Gene Symbols: Tacc1
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Molecular weight:
84,283 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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