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PhLP
Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin. Belongs to the phosducin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein regulator, misc. |
| Chromosomal Location of human Ortholog: 9q33.2 |
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Cellular Component:
cilium; cytoplasm; cytosol
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Molecular Function:
protein binding
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Biological Process:
cell projection organization; heterotrimeric G-protein complex assembly; positive regulation of smoothened signaling pathway; regulation of G protein-coupled receptor signaling pathway; signal transduction; visual perception
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Reference #:
Q13371
(UniProtKB)
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Alt. Names/Synonyms: DKFZp564M1863; PDCL; PHLOP1; PHLP; PhLP1; phosducin like; phosducin-like; Phosducin-like protein
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Gene Symbols: PDCL
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Molecular weight:
34,282 Da
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Basal Isoelectric point:
4.65
Predict pI for various phosphorylation states
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