PEAK1 Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling. Belongs to the protein kinase superfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8q24
Cellular Component:  actin cytoskeleton; focal adhesion
Molecular Function:  ATP binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein kinase activity
Biological Process:  cell migration; focal adhesion assembly; peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of focal adhesion assembly; substrate adhesion-dependent cell spreading
Reference #:  D4A563 (UniProtKB)
Alt. Names/Synonyms: Peak1; Pseudopodium-enriched atypical kinase 1; RGD1312026
Gene Symbols: Peak1
Molecular weight: 191,112 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein