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PAK5
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Predominantly expressed in brain. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of mouse Ortholog: 2|2 F3 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nuclear membrane; nucleoplasm; nucleus; synapse
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Molecular Function:
ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
apoptotic process; cytoskeleton organization; intracellular signal transduction; learning; locomotory behavior; memory; negative regulation of extrinsic apoptotic signaling pathway; phosphorylation; protein phosphorylation; regulation of MAPK cascade
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Reference #:
Q8C015
(UniProtKB)
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Alt. Names/Synonyms: 2900083L08Rik; 6430627N20; MGC117585; OTTMUSP00000017074; OTTMUSP00000017075; p21 (RAC1) activated kinase 5; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; PAK-5; PAK-7; Pak5; Pak7; Serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7
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Gene Symbols: Pak5
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Molecular weight:
80,948 Da
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Basal Isoelectric point:
8.35
Predict pI for various phosphorylation states
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