PAK5 a protein kinase of the STE20 family. Predominantly expressed in brain. Capable of promoting neurite outgrowth, and thus may play a role in neurite development. Associated with microtubule networks and induces microtubule stabilization. Its subcellular localization is tightly regulated during cell cycle progression. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKB subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 2|2 F3
Cellular Component:  cytoplasm; mitochondrion; nucleoplasm; nucleus; synapse
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding; transferase activity
Biological Process:  activation of protein kinase activity; apoptotic process; cell migration; cytoskeleton organization; learning; locomotory behavior; memory; negative regulation of extrinsic apoptotic signaling pathway; phosphorylation; protein phosphorylation; regulation of MAPK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q8C015 (UniProtKB)
Alt. Names/Synonyms: 2900083L08Rik; 6430627N20; MGC117585; OTTMUSP00000017074; OTTMUSP00000017075; p21 protein (Cdc42/Rac)-activated kinase 7; p21-activated kinase 5; p21-activated kinase 7; PAK-5; PAK-7; Pak5; Pak7; Serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 7
Gene Symbols: Pak7
Molecular weight: 80,948 Da
Basal Isoelectric point: 8.35  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein