RANBP2 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. Belongs to the RanBP2 E3 ligase family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; EC; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO conjugating system
Chromosomal Location of Human Ortholog: 20q11
Cellular Component:  annulate lamellae; cytoplasm; cytoplasmic periphery of the nuclear pore complex; mitochondrion; nuclear envelope; nuclear inclusion body; nuclear membrane; nuclear pore; nuclear pore cytoplasmic filaments; nuclear pore nuclear basket; nucleus
Molecular Function:  metal ion binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein-containing complex binding; Ran GTPase binding; SUMO transferase activity
Biological Process:  centrosome localization; NLS-bearing protein import into nucleus; positive regulation of glucokinase activity; positive regulation of GTPase activity; protein folding; protein peptidyl-prolyl isomerization; protein sumoylation; regulation of gluconeogenesis; response to amphetamine
Reference #:  NP_001178533 (RefSeq)
Alt. Names/Synonyms: RAN binding protein 2; Ranbp2; RGD1560047
Gene Symbols: Ranbp2
Molecular weight: 344,395 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene