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MYO3B
Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. Expressed in retina, kidney and testis. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; EC 2.7.11.1; Kinase, protein; Motor; NinaC subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of human Ortholog: 2q31.1 |
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Cellular Component:
cytoplasm; myosin complex; stereocilium tip
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Molecular Function:
actin binding; ATP binding; motor activity; protein serine/threonine kinase activity
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Biological Process:
cochlea morphogenesis; protein phosphorylation; response to stimulus; sensory perception of sound; visual perception
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Reference #:
Q8WXR4
(UniProtKB)
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Alt. Names/Synonyms: MYO3B; myosin IIIB; Myosin-IIIb
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Gene Symbols: MYO3B
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Molecular weight:
151,829 Da
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Basal Isoelectric point:
8.4
Predict pI for various phosphorylation states
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