PNN Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. Belongs to the pinin family. Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 6q23
Cellular Component:  catalytic step 2 spliceosome; cytoplasm; desmosome; exon-exon junction complex; nuclear speck
Biological Process:  cell-cell adhesion
Reference #:  D3ZAY8 (UniProtKB)
Alt. Names/Synonyms: pinin, desmosome associated protein; Pinin, desmosome-associated protein; Pnn
Gene Symbols: Pnn
Molecular weight: 82,610 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
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PNN

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein