MYO3A Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. Strongest expression in retina, retinal pigment epithelial cells, cochlea and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; EC; Kinase, protein; Motor; NinaC subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of mouse Ortholog: 2|2 A3
Cellular Component:  cell projection; cytoplasm; cytoskeleton; cytosol; filamentous actin; filopodium; filopodium tip; myosin complex; photoreceptor inner segment; stereocilium tip
Molecular Function:  actin binding; actin filament binding; ADP binding; ATP binding; calmodulin binding; cytoskeletal motor activity; kinase activity; microfilament motor activity; nucleotide binding; plus-end directed microfilament motor activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  auditory receptor cell stereocilium organization; cochlea morphogenesis; inner ear development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of filopodium assembly; protein autophosphorylation; protein phosphorylation; regulation of actin filament length; response to stimulus; sensory perception of sound; visual perception
Reference #:  Q8K3H5 (UniProtKB)
Alt. Names/Synonyms: 9030416P08Rik; Myo3a; myosin IIIA; Myosin-IIIa
Gene Symbols: Myo3a
Molecular weight: 184,730 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene