pleckstrin iso100 Major protein kinase C substrate of platelets. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 2p14
Cellular Component:  cytoplasm; cytosol; extracellular region; ruffle membrane
Molecular Function:  phosphatidylinositol-3,4-bisphosphate binding; protein binding; protein homodimerization activity; protein kinase C binding
Biological Process:  actin cytoskeleton reorganization; cell projection organization; cortical actin cytoskeleton organization; hematopoietic progenitor cell differentiation; integrin-mediated signaling pathway; negative regulation of calcium-mediated signaling; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of inositol phosphate biosynthetic process; phosphatidylinositol metabolic process; phospholipase C-inhibiting G protein-coupled receptor signaling pathway; platelet aggregation; platelet degranulation; positive regulation of actin filament bundle assembly; positive regulation of actin filament depolymerization; positive regulation of inositol-polyphosphate 5-phosphatase activity; positive regulation of integrin activation; positive regulation of platelet activation; protein kinase C signaling; protein secretion by platelet; regulation of cell diameter; ruffle organization; thrombin-activated receptor signaling pathway; vesicle docking involved in exocytosis
Reference #:  P08567_VAR_R340K (UniProtKB)
Alt. Names/Synonyms: P47; Platelet 47 kDa protein; Pleckstrin; pleckstrin iso100; Pleckstrin VAR_027799 (R340K); PLEK
Gene Symbols: PLEK
Molecular weight: 40,097 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
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pleckstrin iso100

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene