C5aR Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component:  apical part of cell; basolateral plasma membrane; cell surface; integral component of plasma membrane; plasma membrane; secretory granule membrane
Molecular Function:  complement component C5a binding; complement component C5a receptor activity; G protein-coupled receptor activity
Biological Process:  activation of MAPK activity; activation of phospholipase C activity; animal organ regeneration; apoptotic process; cell proliferation in hindbrain; cellular defense response; chemotaxis; cognition; complement component C5a signaling pathway; defense response to Gram-positive bacterium; G protein-coupled receptor signaling pathway; immune response; mRNA transcription by RNA polymerase II; negative regulation of neuron apoptotic process; neutrophil chemotaxis; neutrophil degranulation; positive regulation of angiogenesis; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of vascular endothelial growth factor production; presynapse organization; regulation of amyloid-beta clearance; regulation of astrocyte activation; regulation of complement activation; regulation of microglial cell activation; regulation of tau-protein kinase activity; response to lipopolysaccharide; response to peptidoglycan; sensory perception of chemical stimulus; signal transduction
Reference #:  P21730 (UniProtKB)
Alt. Names/Synonyms: C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a-R; C5AR; C5AR1; C5R1; CD88; complement C5a receptor 1; complement component 5 receptor 1; complement component 5a receptor 1
Gene Symbols: C5AR1
Molecular weight: 39,336 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene