MAP7 Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p12
Cellular Component:  cytosol; microtubule cytoskeleton; plasma membrane
Molecular Function:  receptor binding; structural molecule activity
Biological Process:  cell morphogenesis; cell proliferation; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells; Leydig cell differentiation; microtubule bundle formation; microtubule cytoskeleton organization; nucleus organization; organ growth; response to osmotic stress; response to retinoic acid; Sertoli cell development; spermatogenesis
Reference #:  NP_001099740 (RefSeq)
Alt. Names/Synonyms: Map7; microtubule-associated protein 7; Mtap7
Gene Symbols: Map7
Molecular weight: 84,731 Da
Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein