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MAP7
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 1p12 |
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Cellular Component:
axon; cytosol; microtubule cytoskeleton; plasma membrane
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Molecular Function:
signaling receptor binding
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Biological Process:
cell morphogenesis; cell population proliferation; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells; Leydig cell differentiation; microtubule bundle formation; microtubule cytoskeleton organization; nucleus organization; organ growth; protein localization to plasma membrane; response to osmotic stress; response to retinoic acid; Sertoli cell development; spermatogenesis
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Reference #:
NP_001099740
(RefSeq)
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Alt. Names/Synonyms: Map7; microtubule-associated protein 7; Mtap7
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Gene Symbols: Map7
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Molecular weight:
84,731 Da
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Basal Isoelectric point:
9.82
Predict pI for various phosphorylation states
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