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MAP7
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 1p12 |
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Cellular Component:
cytosol; microtubule cytoskeleton; plasma membrane
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Molecular Function:
receptor binding; structural molecule activity
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Biological Process:
cell morphogenesis; cell proliferation; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells; Leydig cell differentiation; microtubule bundle formation; microtubule cytoskeleton organization; nucleus organization; organ growth; response to osmotic stress; response to retinoic acid; Sertoli cell development; spermatogenesis
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Reference #:
NP_001099740
(RefSeq)
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Alt. Names/Synonyms: Map7; microtubule-associated protein 7; Mtap7
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Gene Symbols: Map7
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Molecular weight:
84,731 Da
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Basal Isoelectric point:
9.82
Predict pI for various phosphorylation states
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