MAP7
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
Protein type: Microtubule-binding; Motility/polarity/chemotaxis |
Chromosomal Location of Human Ortholog: 1p12 |
Cellular Component:
cytosol; microtubule cytoskeleton; plasma membrane
|
Molecular Function:
receptor binding; structural molecule activity
|
Biological Process:
cell morphogenesis; cell proliferation; fertilization; germ cell development; glycosphingolipid metabolic process; homeostasis of number of cells; Leydig cell differentiation; microtubule bundle formation; microtubule cytoskeleton organization; nucleus organization; organ growth; response to osmotic stress; response to retinoic acid; Sertoli cell development; spermatogenesis
|
Reference #:
NP_001099740
(RefSeq)
|
Alt. Names/Synonyms: Map7; microtubule-associated protein 7; Mtap7
|
Gene Symbols: Map7
|
Molecular weight:
84,731 Da
|
Basal Isoelectric point:
9.82
Predict pI for various phosphorylation states
|