eIF3-epsilon Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. Belongs to the eIF-3 subunit F family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 7|7 E3
Cellular Component:  cytoplasm; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m
Molecular Function:  cysteine-type peptidase activity; hydrolase activity; peptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity; translation initiation factor binding
Biological Process:  IRES-dependent viral translational initiation; protein deubiquitination; proteolysis; translation; translational initiation
Reference #:  Q9DCH4 (UniProtKB)
Alt. Names/Synonyms: 0610037M02Rik; AA409853; eIF-3-epsilon; eIF3 p47; eIF3-epsilon; Eif3f; Eif3s5; Eukaryotic translation initiation factor 3 subunit 5; eukaryotic translation initiation factor 3 subunit 5 epsilon; Eukaryotic translation initiation factor 3 subunit F; eukaryotic translation initiation factor 3, subunit 5 (epsilon); eukaryotic translation initiation factor 3, subunit F; MGC90606; OTTMUSP00000031829
Gene Symbols: Eif3f
Molecular weight: 37,984 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Select Structure to View Below

eIF3-epsilon

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene