LIP8 Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q24
Cellular Component:  centriole; centrosome; cytosol
Molecular Function:  protein domain specific binding
Biological Process:  centriole replication; centrosome separation; mitotic cytokinetic process; regulation of cilium assembly
Reference #:  XP_220600 (RefSeq)
Alt. Names/Synonyms: centrobin, centriole duplication and spindle assembly protein; centrobin, centrosomal BRCA2 interacting protein; Cntrob; Lip8; LYST-interacting protein 8; RGD1307488
Gene Symbols: Cntrob
Molecular weight: 100,885 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene