eIF3-epsilon Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. Belongs to the eIF-3 subunit F family. Note: This description may include information from UniProtKB.
Protein type: EC; Translation; Translation initiation
Chromosomal Location of human Ortholog: 11p15.4
Cellular Component:  cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex
Molecular Function:  protein binding; thiol-dependent ubiquitin-specific protease activity; translation initiation factor activity
Biological Process:  formation of cytoplasmic translation initiation complex; IRES-dependent viral translational initiation; protein deubiquitination; translational initiation
Disease: Intellectual Developmental Disorder, Autosomal Recessive 67
Reference #:  O00303 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3 p47; eIF3-epsilon; eIF3-p47; EIF3F; EIF3S5; Eukaryotic translation initiation factor 3 subunit 5; Eukaryotic translation initiation factor 3 subunit F; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit F; MRT67
Gene Symbols: EIF3F
Molecular weight: 37,564 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene