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eIF3-epsilon
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. Belongs to the eIF-3 subunit F family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 11p15.4 |
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Cellular Component:
cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex
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Molecular Function:
protein binding; thiol-dependent ubiquitin-specific protease activity; translation initiation factor activity
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Biological Process:
formation of cytoplasmic translation initiation complex; IRES-dependent viral translational initiation; protein deubiquitination; translational initiation
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Disease: Intellectual Developmental Disorder, Autosomal Recessive 67
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Reference #:
O00303
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme eIF3f; eIF-3-epsilon; eIF3 p47; eIF3-epsilon; eIF3-p47; EIF3F; EIF3S5; Eukaryotic translation initiation factor 3 subunit 5; Eukaryotic translation initiation factor 3 subunit F; eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD); eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa; eukaryotic translation initiation factor 3, subunit F; MRT67
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Gene Symbols: EIF3F
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Molecular weight:
37,564 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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CST Pathways:
Translational Control
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