PEAR1 When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Belongs to the MEGF family. Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of rat Ortholog: 2q34
Cellular Component:  integral component of membrane; phagocytic cup; plasma membrane
Molecular Function:  signaling receptor activity
Biological Process:  negative regulation of Notch signaling pathway; phosphatidylinositol 3-kinase signaling; platelet aggregation; protein kinase B signaling; recognition of apoptotic cell
Reference #:  B5DEG9 (UniProtKB)
Alt. Names/Synonyms: MGC188434; Pear1; Pear1 protein; platelet endothelial aggregation receptor 1; RGD1305653
Gene Symbols: Pear1
Molecular weight: 110,368 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept