SPTAN1 Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p12
Cellular Component:  cortical cytoskeleton; cuticular plate; cytosol; fascia adherens; intracellular membrane-bounded organelle; lateral plasma membrane; membrane; microtubule cytoskeleton; paranode region of axon; plasma membrane; protein-containing complex; spectrin; Z disc
Molecular Function:  actin binding; calcium ion binding; calmodulin binding; protein binding; protein heterodimerization activity; protein-containing complex binding; spectrin binding; syntaxin binding
Biological Process:  actin cytoskeleton reorganization; actin filament capping
Reference #:  P16086 (UniProtKB)
Alt. Names/Synonyms: a--fodrin; A2a; alpha II spectrin; alpha-fodrin; Alpha-II spectrin; alpha-spectrin 2; brain alpha-spectrin; Fodrin alpha chain; inhibitory protein factor; IPF; noerythroid alpha-spectrin 2; nonerythroid alpha-spectrin 2; Spectrin alpha chain, brain; Spectrin alpha chain, non-erythrocytic 1; Spectrin, non-erythroid alpha chain; Spna2; Spta2; Sptan1
Gene Symbols: Sptan1
Molecular weight: 284,638 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene