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SRC-1
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. Belongs to the SRC/p160 nuclear receptor coactivator family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor |
| Chromosomal Location of rat Ortholog: 6q14 |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus; plasma membrane; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; nuclear estrogen receptor binding; nuclear receptor binding; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coactivator activity
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Biological Process:
cellular response to hormone stimulus; cellular response to Thyroglobulin triiodothyronine; cerebellum development; cerebral cortex development; estrous cycle; hippocampus development; hypothalamus development; labyrinthine layer morphogenesis; lactation; male gonad development; male mating behavior; mRNA transcription by RNA polymerase II; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter by galactose; regulation of thyroid hormone mediated signaling pathway; response to estradiol; response to hormone; response to progesterone; response to retinoic acid
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Reference #:
NP_001101482
(RefSeq)
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Alt. Names/Synonyms: Ncoa1; nuclear receptor coactivator 1; SRC-1; steroid receptor coactivator 1
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Gene Symbols: Ncoa1
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Molecular weight:
153,761 Da
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Basal Isoelectric point:
6.07
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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