IRF2BP1 Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation. Belongs to the IRF2BP family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Transcription, coactivator/corepressor; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription corepressor activity; ubiquitin protein ligase activity
Biological Process:  negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; protein polyubiquitination
Reference #:  D4AAZ8 (UniProtKB)
Alt. Names/Synonyms: interferon regulatory factor 2 binding protein 1; Interferon regulatory factor 2 binding protein 1 (Predicted); interferon regulatory factor 2-binding protein 1; Irf2bp1
Gene Symbols: Irf2bp1
Molecular weight: 61,795 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Select Structure to View Below

IRF2BP1

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein