ICAP1 Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q16
Cellular Component:  cell periphery; cytoplasm; cytoskeleton; cytosol; lamellipodium; microtubule organizing center; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle
Molecular Function:  GDP-dissociation inhibitor activity; integrin binding; kinase binding; protein kinase binding; protein-containing complex binding
Biological Process:  activation of protein kinase B activity; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell-matrix adhesion; cellular response to fibroblast growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; integrin activation; integrin-mediated signaling pathway; myoblast migration; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast migration; negative regulation of focal adhesion assembly; negative regulation of protein binding; negative regulation of protein kinase activity; negative regulation of protein targeting to membrane; negative regulation of substrate adhesion-dependent cell spreading; positive regulation of cell proliferation; positive regulation of endothelial cell migration; positive regulation of focal adhesion assembly; positive regulation of Notch signaling pathway; positive regulation of protein kinase B signaling; positive regulation of protein targeting to membrane; positive regulation of stress fiber assembly; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; protein transport; receptor clustering; regulation of blood vessel size; regulation of cell adhesion mediated by integrin; regulation of GTPase activity; regulation of integrin-mediated signaling pathway; tube formation
Reference #:  B5DFL3 (UniProtKB)
Alt. Names/Synonyms: ICAP1; integrin beta 1 binding protein 1; Integrin beta 1 binding protein 1 (Predicted), isoform CRA_a; integrin beta-1-binding protein 1; Itgb1bp1
Gene Symbols: Itgb1bp1
Molecular weight: 21,692 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
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ICAP1

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein