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BHMT
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Found exclusively in liver and kidney. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.5; Methyltransferase |
| Chromosomal Location of rat Ortholog: 2q12 |
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Cellular Component:
cytosol; extracellular exosome; nucleus; protein-containing complex
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Molecular Function:
betaine-homocysteine S-methyltransferase activity; identical protein binding; methyltransferase activity; protein-containing complex binding; zinc ion binding
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Biological Process:
'de novo' L-methionine biosynthetic process; amino-acid betaine catabolic process; amino-acid betaine metabolic process; L-methionine salvage; methionine biosynthetic process; methylation; protein methylation; response to organonitrogen compound; S-adenosylmethionine metabolic process
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Reference #:
O09171
(UniProtKB)
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Alt. Names/Synonyms: Betaine--homocysteine S-methyltransferase 1; betaine-homocysteine methyltransferase; Bhmt; O09171
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Gene Symbols: Bhmt
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Molecular weight:
44,976 Da
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Basal Isoelectric point:
8.02
Predict pI for various phosphorylation states
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