HAAO Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC; Oxidoreductase
Chromosomal Location of rat Ortholog: 6q12
Cellular Component:  cytoplasm; cytosol; mitochondrial membrane
Molecular Function:  3-hydroxyanthranilate 3,4-dioxygenase activity; ferrous iron binding; iron ion binding; oxygen binding
Biological Process:  'de novo' NAD biosynthetic process from tryptophan; anthranilate metabolic process; NAD biosynthetic process; neuron cellular homeostasis; oxidation-reduction process; quinolinate biosynthetic process; quinolinate metabolic process; response to cadmium ion; response to zinc ion; tryptophan catabolic process
Reference #:  P46953 (UniProtKB)
Alt. Names/Synonyms: 3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; Haao; HAD; P46953
Gene Symbols: Haao
Molecular weight: 32,582 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein