DOK3 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. Belongs to the DOK family. Type A subfamily. Expressed in spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p14
Cellular Component:  cytoplasm; plasma membrane
Biological Process:  Ras protein signal transduction
Reference #:  B2RYG7 (UniProtKB)
Alt. Names/Synonyms: B2RYG7; Docking protein 3; Dok3; downstream of tyrosine kinase 3
Gene Symbols: Dok3
Molecular weight: 48,190 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein