FBI1 Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions. Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms. That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300. Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors. Also directly interacts with transcription factors like SP1 to prevent their binding to DNA. Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes. Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Involved in the switch between fetal and adult globin expression during erythroid cells maturation. Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription. Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation. Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation. Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis. Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation. Plays a key role in the differentiation of lymphoid progenitors into B and T lineages. Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes. Also regulates osteoclast differentiation. May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ. Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair. May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1. Widely expressed (PubMed:9927193). In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) (PubMed:15662416). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) (PubMed:15662416). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) (PubMed:15662416). Expressed in adipose tissues (PubMed:14701838). Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q11
Cellular Component:  cytoplasm; DNA-dependent protein kinase complex; nucleus; NuRD complex; site of double-strand break
Molecular Function:  activating transcription factor binding; androgen receptor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone acetyltransferase binding; metal ion binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; SMAD binding; transcription corepressor activity; transcription corepressor binding
Biological Process:  B cell differentiation; chromatin organization; chromatin remodeling; double-strand break repair via classical nonhomologous end joining; erythrocyte maturation; fat cell differentiation; negative regulation of androgen receptor signaling pathway; negative regulation of Notch signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein localization to nucleus; regulation of alternative mRNA splicing, via spliceosome; regulation of apoptotic process; regulation of DNA-binding transcription factor activity; regulation of glycolytic process; regulation of osteoclast differentiation; regulation of transcription regulatory region DNA binding; regulation of transcription, DNA-templated; transcription, DNA-templated
Reference #:  Q9QZ48 (UniProtKB)
Alt. Names/Synonyms: FBI1; leukemia/lymphoma related factor; leukemia/lymphoma-related factor; Lrf; OCZF; osteoclast-derived zinc finger protein; Q9QZ48; Zbtb7; Zbtb7a; zinc finger and BTB domain containing 7a; Zinc finger and BTB domain-containing protein 7A
Gene Symbols: Zbtb7a
Molecular weight: 60,543 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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FBI1

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein