PITPNM1 Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of rat Ortholog: 1q43
Cellular Component:  cell body; cleavage furrow; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; endoplasmic reticulum membrane; Golgi cisterna membrane; lipid droplet; microtubule organizing center; midbody
Molecular Function:  calcium ion binding; phosphatidic acid binding; phosphatidylcholine binding; phosphatidylcholine transporter activity; phosphatidylinositol binding; phosphatidylinositol transporter activity; receptor tyrosine kinase binding
Biological Process:  phospholipid transport; protein transport
Reference #:  Q5U2N3 (UniProtKB)
Alt. Names/Synonyms: Membrane-associated phosphatidylinositol transfer protein 1; MGC95131; NIR-2; phosphatidylinositol membrane-associated; phosphatidylinositol transfer protein, membrane-associated 1; Pitpnm; PITPnm 1; Pitpnm1; pyk2 N-terminal domain-interacting receptor 2; Q5U2N3
Gene Symbols: Pitpnm1
Molecular weight: 134,984 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein