ARNT Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 2q34
Cellular Component:  cytoplasm; nuclear body; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  aryl hydrocarbon receptor binding; DNA binding; DNA-binding transcription factor activity; enhancer binding; nuclear receptor activity; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription factor binding
Biological Process:  cell differentiation; embryonic placenta development; intracellular receptor signaling pathway; positive regulation of hormone biosynthetic process; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; regulation of transcription, DNA-templated; response to hypoxia; response to toxic substance
Reference #:  P41739 (UniProtKB)
Alt. Names/Synonyms: Arnt; Arnt1; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; dioxin receptor, nuclear translocator; HIF-1 beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1-beta; P41739
Gene Symbols: Arnt
Molecular weight: 88,221 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  mTOR Signaling
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ARNT

Protein Structure Not Found.


Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept