HGK Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 1|1 B
Cellular Component:  cytoplasm; focal adhesion
Molecular Function:  ATP binding; creatine kinase activity; kinase activity; microtubule binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; intracellular signal transduction; MAPK cascade; negative regulation of apoptotic process; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of neuron projection development; negative regulation of neuron projection regeneration; neuron projection morphogenesis; phosphorylation; positive regulation of adherens junction organization; positive regulation of ARF protein signal transduction; positive regulation of cell migration; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of keratinocyte migration; protein phosphorylation; regulation of JNK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  P97820 (UniProtKB)
Alt. Names/Synonyms: 9430080K19Rik; AU043147; AU045934; AW046177; HGK; HPK/GCK-like kinase HGK; M4K4; Map4k4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; mitogen activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; NCK interacting kinase; Nck-interacting kinase; Nik; ZC1
Gene Symbols: Map4k4
Molecular weight: 140,602 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene