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HGK
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of mouse Ortholog: 1|1 B |
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Cellular Component:
cytoplasm; focal adhesion
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Molecular Function:
ATP binding; creatine kinase activity; kinase activity; microtubule binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
intracellular signal transduction; MAPK cascade; negative regulation of apoptotic process; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of neuron projection development; negative regulation of neuron projection regeneration; neuron projection morphogenesis; phosphorylation; positive regulation of ARF protein signal transduction; positive regulation of cell migration; positive regulation of focal adhesion assembly; positive regulation of focal adhesion disassembly; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of keratinocyte migration; protein phosphorylation; regulation of JNK cascade; regulation of MAPK cascade
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Reference #:
P97820
(UniProtKB)
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Alt. Names/Synonyms: 9430080K19Rik; AU043147; AU045934; AW046177; HGK; HPK/GCK-like kinase HGK; M4K4; Map4k4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; mitogen activated protein kinase kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase kinase 4; NCK interacting kinase; Nck-interacting kinase; Nik; ZC1
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Gene Symbols: Map4k4
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Molecular weight:
140,602 Da
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Basal Isoelectric point:
7.1
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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