E2F4 Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  nuclear chromatin; nucleoplasm
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; promoter-specific chromatin binding; protein binding; protein dimerization activity; protein domain specific binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  animal organ morphogenesis; blood circulation; cell volume homeostasis; centriole assembly; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epithelial cell development; motile cilium assembly; multi-ciliated epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of cell proliferation; regulation of transcription involved in G1/S transition of mitotic cell cycle
Reference #:  Q16254 (UniProtKB)
Alt. Names/Synonyms: E2F transcription factor 4; E2F transcription factor 4, p107/p130-binding; E2F-4; E2F4; p107/p130-binding protein; Transcription factor E2F4
Gene Symbols: E2F4
Molecular weight: 43,960 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene