Exportin-7 Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family. Note: This description may include information from UniProtKB.
Protein type: Karyopherin; Nuclear export; Nuclear import
Chromosomal Location of Human Ortholog: 15p11
Cellular Component:  cytoplasm; nuclear pore; nucleus
Molecular Function:  nuclear export signal receptor activity; Ran GTPase binding
Biological Process:  intracellular protein transport; protein export from nucleus
Reference #:  NP_001101856 (RefSeq)
Alt. Names/Synonyms: exportin 7; exportin-7; Xpo7; Xpo7 protein
Gene Symbols: Xpo7
Molecular weight: 123,780 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
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Exportin-7

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene