KHS2 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 6q11
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase kinase kinase activity; protein serine/threonine kinase activity; SH3 domain binding
Biological Process:  activation of MAPKKK activity; activation of protein kinase activity; intracellular signal transduction; MAPK cascade; protein phosphorylation; response to tumor necrosis factor; response to UV; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q924I2 (UniProtKB)
Alt. Names/Synonyms: Germinal center kinase-related protein kinase; GLK; KHS2; M4K3; Map4k3; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; Mitogen-activated protein kinase kinase kinase kinase 3
Gene Symbols: Map4k3
Molecular weight: 98,679 Da
Basal Isoelectric point: 8.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene