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KHS2
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of rat Ortholog: 6q11 |
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Cellular Component:
cytoplasm
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Molecular Function:
ATP binding; MAP kinase kinase kinase kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; SH3 domain binding
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Biological Process:
intracellular signal transduction; MAPK cascade; protein phosphorylation; response to tumor necrosis factor; response to UV
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Reference #:
Q924I2
(UniProtKB)
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Alt. Names/Synonyms: Germinal center kinase-related protein kinase; GLK; KHS2; M4K3; Map4k3; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; Mitogen-activated protein kinase kinase kinase kinase 3
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Gene Symbols: Map4k3
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Molecular weight:
98,679 Da
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Basal Isoelectric point:
8.23
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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