BPAG1 a protein of the plakin family. Plakins are multi-domain proteins that have been shown to interact with microtubules, actin filaments and intermediate filaments, as well as proteins found in cellular junctions. Ten alternatively spliced human isoforms have been reported. BPAG1 has neuronal and muscle isoforms that consist of actin-binding and microtubule-binding domains at either end separated by a plakin domain and many spectrin repeats. Bpag1 isoforms with different N-termini may have differing roles. The plakin domain contains an apparent nuclear localization signal. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q21
Cellular Component:  actin cytoskeleton; axon; cell leading edge; cytoplasm; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum membrane; focal adhesion; hemidesmosome; intermediate filament cytoskeleton; membrane; microtubule cytoskeleton; neurofilament cytoskeleton; nuclear envelope; nucleus; perinuclear region of cytoplasm; postsynaptic density; sarcolemma; stress fiber; Z disc
Molecular Function:  actin binding; calcium ion binding; integrin binding; microtubule binding; microtubule plus-end binding; protein C-terminus binding; protein homodimerization activity
Biological Process:  axonogenesis; cell motility; cytoplasmic microtubule organization; cytoskeleton organization; hemidesmosome assembly; intermediate filament cytoskeleton organization and biogenesis; intracellular transport; maintenance of cell polarity; microtubule cytoskeleton organization; regulation of microtubule polymerization or depolymerization; response to wounding; retrograde axon cargo transport
Reference #:  F1M118 (UniProtKB)
Alt. Names/Synonyms: Dst; dystonin
Gene Symbols: Dst
Molecular weight: 829,277 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein