DNCH1 Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. Belongs to the dynein heavy chain family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 6q32
Cellular Component:  axon; cell cortex; centrosome; cytoplasm; cytoplasmic dynein complex; cytoplasmic microtubule; dynein complex; filopodium; manchette; microtubule; neuronal cell body; nuclear envelope
Molecular Function:  ATP binding; ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; dynein light chain binding; dynein light intermediate chain binding; microtubule motor activity; protein binding
Biological Process:  cell division; cellular response to 3,3',5-triiodo-L-thyronine; cellular response to nerve growth factor stimulus; cytoplasmic microtubule organization; cytoplasmic mRNA processing body assembly; establishment of spindle localization; microtubule-based movement; minus-end-directed vesicle transport along microtubule; mitotic cell cycle; nuclear migration; positive regulation of cold-induced thermogenesis; positive regulation of intracellular transport; positive regulation of spindle assembly; regulation of metaphase plate congression; regulation of mitotic spindle organization; retrograde axonal transport; spermatid development; stress granule assembly
Reference #:  M0R9X8 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; Dnch1; Dnchc1; Dync1h1; dynein cytoplasmic 1 heavy chain 1; Dynein heavy chain; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy chain 1; MAP 1C
Gene Symbols: Dync1h1
Molecular weight: 532,047 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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DNCH1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene