CSPG2 May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Belongs to the aggrecan/versican proteoglycan family. Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q12
Cellular Component:  cell surface; collagen-containing extracellular matrix; extracellular matrix; perineuronal net; synapse
Molecular Function:  calcium ion binding; carbohydrate binding; hyaluronic acid binding; low-density lipoprotein particle binding; protein phosphatase binding
Biological Process:  axon regeneration; cell adhesion; central nervous system development; glial cell migration; heart development; response to wounding; skeletal system development; ureteric bud development
Reference #:  NP_001164029 (RefSeq)
Alt. Names/Synonyms: Chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan 2 (versican); Chondroitin sulfate proteoglycan core protein 2; Cspg2; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M; Vcan; versican; Versican core protein
Gene Symbols: Vcan
Molecular weight: 366,658 Da
Basal Isoelectric point: 4.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene