coronin 1C Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells. Isoform 3: Involved in myogenic differentiation. Belongs to the WD repeat coronin family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 12q16
Cellular Component:  actin cytoskeleton; cytoskeleton; endosome membrane; flotillin complex; lamellipodium; lateral plasma membrane
Molecular Function:  actin filament binding; Rac GTPase binding
Biological Process:  actin cytoskeleton organization; actin filament organization; activation of GTPase activity; cell migration; endosomal transport; endosome membrane tubulation; establishment of protein localization; membrane fission; negative regulation of epithelial cell migration; negative regulation of focal adhesion assembly; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of protein phosphorylation; negative regulation of substrate adhesion-dependent cell spreading; neural crest cell migration; positive regulation of lamellipodium morphogenesis; regulation of epithelial cell migration; regulation of fibroblast migration; regulation of focal adhesion assembly; regulation of protein phosphorylation; regulation of ruffle assembly; regulation of substrate adhesion-dependent cell spreading
Reference #:  NP_001102797 (RefSeq)
Alt. Names/Synonyms: Coro1c; coronin 1C; coronin, actin binding protein 1C; RGD1564490
Gene Symbols: Coro1c
Molecular weight: 53,178 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
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coronin 1C

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene