KHS1 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. Note: This description may include information from UniProtKB.
Protein type: EC; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of mouse Ortholog: 12|12 C2
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; intracellular signal transduction; phosphorylation; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q8BPM2 (UniProtKB)
Alt. Names/Synonyms: 4432415E19Rik; GCK; GCKR; KHS; KHS1; M4K5; Map4k5; MAPK/ERK kinase kinase kinase 5; MAPKKK; MAPKKKK5; MEK kinase kinase 5; MEKKK 5; Mitogen-activated protein kinase kinase kinase kinase 5
Gene Symbols: Map4k5
Molecular weight: 95,045 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene