CENTD1 Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of Human Ortholog: 14p11
Cellular Component: 
Molecular Function:  GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding
Biological Process:  positive regulation of GTPase activity; signal transduction
Reference #:  ENSRNOP00000003014 (Ensembl)
Alt. Names/Synonyms: Arap2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; centaurin, delta 1; Centd1
Gene Symbols: Arap2
Molecular weight: 192,715 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
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CENTD1

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein