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GCK
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family |
| Chromosomal Location of mouse Ortholog: 19|19 A |
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Cellular Component:
cytoplasm; Golgi apparatus; membrane; plasma membrane
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Molecular Function:
ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
immune system process; innate immune response; intracellular signal transduction; phosphorylation; positive regulation of JNK cascade; positive regulation of JUN kinase activity; protein phosphorylation; vesicle targeting
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Reference #:
Q61161
(UniProtKB)
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Alt. Names/Synonyms: AI385662; BL4; BL44; GCK; Germinal center kinase; M4K2; Map4k2; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; MGC143893; MGC143894; mitogen activated protein kinase kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase kinase 2; OTTMUSP00000020164; RAB8 interacting protein; Rab8-interacting protein; Rab8ip
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Gene Symbols: Map4k2
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Molecular weight:
91,265 Da
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Basal Isoelectric point:
6
Predict pI for various phosphorylation states
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CST Pathways:
SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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