RNF213 E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity. Belongs to the AAA ATPase family. Widely expressed (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 10q32.3
Cellular Component:  cytoplasm; cytosol; nucleolus
Molecular Function:  ATPase activity; ubiquitin-protein transferase activity
Biological Process:  angiogenesis; negative regulation of non-canonical Wnt signaling pathway; protein autoubiquitination; protein homooligomerization; protein ubiquitination; sprouting angiogenesis; ubiquitin-dependent protein catabolic process
Reference #:  XP_221191 (RefSeq)
Alt. Names/Synonyms: RGD1308168; ring finger protein 213; Rnf213
Gene Symbols: Rnf213
Molecular weight: 587,307 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
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RNF213

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept