STLK3 May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; FRAY subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of mouse Ortholog: 2|2 C1.3
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; cytosol; extrinsic component of membrane; intracellular membrane-bounded organelle; membrane; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of MAPK activity; activation of protein kinase activity; cellular hypotonic response; cellular response to chemokine; chemokine (C-X-C motif) ligand 12 signaling pathway; intracellular signal transduction; ion homeostasis; maintenance of lens transparency; negative regulation of creatine transmembrane transporter activity; negative regulation of pancreatic juice secretion; negative regulation of potassium ion transmembrane transport; negative regulation of potassium ion transmembrane transporter activity; negative regulation of protein phosphorylation; negative regulation of sodium ion transmembrane transporter activity; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of ion transmembrane transporter activity; positive regulation of potassium ion transport; positive regulation of T cell chemotaxis; protein autophosphorylation; protein phosphorylation; regulation of blood pressure; regulation of inflammatory response; signal transduction by protein phosphorylation; signal transduction by trans-phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9Z1W9 (UniProtKB)
Alt. Names/Synonyms: AW227544; AW556857; DCHT; kidney-specific SPAK; OTTMUSP00000013981; RF00; RF005; Rnl5; serine/threonine kinase 39; serine/threonine kinase 39, STE20/SPS1 homolog; serine/threonine kinase 39, STE20/SPS1 homolog (yeast); Serine/threonine-protein kinase 39; Spak; Ste-20 related kinase; Ste-20-related kinase; STE20/SPS1-related proline-alanine-rich protein kinase; Stk39; STLK3
Gene Symbols: Stk39
Molecular weight: 60,320 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene