ASXL2 Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with KAT6A generates a KAT6A-ASXL2 fusion protein. Belongs to the Asx family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6q14
Cellular Component:  nucleoplasm; nucleus; PR-DUB complex
Molecular Function:  chromatin binding; DNA binding; peroxisome proliferator activated receptor binding
Biological Process:  adult heart development; animal organ morphogenesis; embryonic skeletal system morphogenesis; heart development; heart morphogenesis; negative regulation of transcription by RNA polymerase II; positive regulation of bone mineralization involved in bone maturation; positive regulation of fat cell differentiation; positive regulation of histone H3-K27 trimethylation; positive regulation of osteoclast differentiation; positive regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of transcription by RNA polymerase II
Reference #:  NP_001101481 (RefSeq)
Alt. Names/Synonyms: additional sex combs like 2; additional sex combs like 2 (Drosophila); additional sex combs like 2, transcriptional regulator; Asxl2
Gene Symbols: Asxl2
Molecular weight: 106,193 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept