Nik Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 11 E1|11 66.8 cM
Cellular Component:  cytoplasm; cytosol; fibrillar center; intracellular membrane-bounded organelle; nucleus
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; defense response to virus; I-kappaB kinase/NF-kappaB signaling; immune response; phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9WUL6 (UniProtKB)
Alt. Names/Synonyms: aly; alymphoplasia; M3K14; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; Nik; OTTMUSP00000002951; protein kinase; Serine/threonine-protein kinase NIK
Gene Symbols: Map3k14
Molecular weight: 103,080 Da
Basal Isoelectric point: 7.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Nik

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene