GOSR1 Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. Belongs to the GOSR1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  cytosol; Golgi apparatus; Golgi membrane; integral component of membrane; SNARE complex; transport vesicle
Molecular Function:  SNAP receptor activity
Biological Process:  ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; protein transport; retrograde transport, endosome to Golgi
Reference #:  O95249 (UniProtKB)
Alt. Names/Synonyms: 28 kDa cis-Golgi SNARE p28; 28 kDa Golgi SNARE protein; cis-golgi SNARE; golgi integral membrane protein 2; Golgi SNAP receptor complex member 1; Golgi SNARE 28 kDa; GOLIM2; GOS-28; GOS28; GOS28/P28; GOSR1; GS28; P28
Gene Symbols: GOSR1
Molecular weight: 28,613 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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