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GluR4
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 11q22.3 |
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Cellular Component:
AMPA glutamate receptor complex; dendritic spine; endocytic vesicle membrane; neuronal cell body; plasma membrane; postsynaptic density membrane
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Molecular Function:
AMPA glutamate receptor activity; amyloid-beta binding; ionotropic glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; monoatomic ion transmembrane transport; negative regulation of smooth muscle cell apoptotic process; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential; synaptic transmission, glutamatergic
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Disease: Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
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Reference #:
P48058
(UniProtKB)
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Alt. Names/Synonyms: AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; GLUR4; GLUR4C; GLURD; glutamate ionotropic receptor AMPA type subunit 4; Glutamate receptor 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; GRIA4; NEDSGA
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Gene Symbols: GRIA4
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Molecular weight:
100,871 Da
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Basal Isoelectric point:
8.32
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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Parkinson's Disease
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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