CYP51A1 Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase
Chromosomal Location of human Ortholog: 7q21.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  heme binding; iron ion binding; sterol 14-demethylase activity
Biological Process:  cholesterol biosynthetic process; demethylation; negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; negative regulation of protein secretion; regulation of cholesterol biosynthetic process; steroid biosynthetic process; sterol metabolic process
Reference #:  Q16850 (UniProtKB)
Alt. Names/Synonyms: CP51; CP51A; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrome P450 51A1; cytochrome P450 family 51 subfamily A member 1; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51, subfamily A, polypeptide 1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450-14DM; P450L1; Sterol 14-alpha demethylase
Gene Symbols: CYP51A1
Molecular weight: 57,278 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein