|
CYP51A1
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. Ubiquitously expressed with highest levels in testis, ovary, adrenal, prostate, liver, kidney and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Demethylase; EC 1.14.13.70; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase |
| Chromosomal Location of human Ortholog: 7q21.2 |
|
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane
|
|
Molecular Function:
heme binding; iron ion binding; sterol 14-demethylase activity
|
|
Biological Process:
cholesterol biosynthetic process; demethylation; negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; negative regulation of protein secretion; regulation of cholesterol biosynthetic process; steroid biosynthetic process; sterol metabolic process
|
|
Reference #:
Q16850
(UniProtKB)
|
|
Alt. Names/Synonyms: CP51; CP51A; CYP51; CYP51A1; CYPL1; CYPLI; Cytochrome P450 51A1; cytochrome P450 family 51 subfamily A member 1; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450, family 51, subfamily A, polypeptide 1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; lanosterol 14-alpha-demethylase; LDM; P450-14DM; P450L1; Sterol 14-alpha demethylase
|
|
Gene Symbols: CYP51A1
|
|
Molecular weight:
57,278 Da
|
|
Basal Isoelectric point:
8.72
Predict pI for various phosphorylation states
|
